Martin O Leach Selected Research

Necrosis

4/2018	Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.
6/2012	Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer.

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Martin O Leach Research Topics

Disease

52	Neoplasms (Cancer) 12/2021 - 09/2003
11	Breast Neoplasms (Breast Cancer) 12/2018 - 04/2002
9	Carcinoma (Carcinomatosis) 10/2018 - 04/2005
8	Neoplasm Metastasis (Metastasis) 12/2021 - 07/2008
8	Prostatic Neoplasms (Prostate Cancer) 10/2018 - 04/2002
7	Hypoxia (Hypoxemia) 04/2018 - 11/2003
5	Melanoma (Melanoma, Malignant) 01/2020 - 07/2010
5	Squamous Cell Carcinoma of Head and Neck 01/2018 - 01/2016
4	Glioma (Gliomas) 03/2019 - 01/2002
3	Glioblastoma (Glioblastoma Multiforme) 07/2017 - 01/2014
3	Colonic Neoplasms (Colon Cancer) 02/2012 - 11/2003
2	Sarcoma (Soft Tissue Sarcoma) 01/2019 - 01/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2018 - 04/2011
2	Necrosis 04/2018 - 06/2012
2	Circulating Neoplastic Cells 04/2017 - 01/2016
2	Fatigue 11/2014 - 04/2011
2	Colorectal Neoplasms (Colorectal Cancer) 10/2013 - 04/2007
1	Malignant Mesothelioma 12/2021
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Brain Diseases (Brain Disorder) 01/2019
1	Fibrosis (Cirrhosis) 04/2018
1	Hyperoxia 01/2018
1	Ductal Carcinoma 01/2018
1	Ovarian Neoplasms (Ovarian Cancer) 12/2017
1	Lymphoma (Lymphomas) 11/2017
1	Lung Neoplasms (Lung Cancer) 03/2017
1	Liver Neoplasms (Liver Cancer) 03/2017
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 01/2017

Drug/Important Bio-Agent (IBA)

31	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2004
11	Phosphorylcholine (Phosphocholine)IBA 12/2017 - 09/2003
10	Choline (Choline Chloride)IBA 01/2021 - 01/2006
9	Pharmaceutical PreparationsIBA 01/2018 - 07/2008
9	Lactic Acid (Lactate)FDA LinkGeneric 11/2017 - 07/2013
8	Protons (Proton)IBA 01/2020 - 01/2002
6	Phospholipids (Phosphatides)FDA LinkGeneric 12/2017 - 11/2003
6	Phosphorus (Red Phosphorus)IBA 01/2014 - 11/2003
4	pimonidazoleIBA 04/2018 - 08/2007
4	PI103IBA 01/2017 - 07/2010
4	EnzymesIBA 10/2013 - 05/2009
4	Choline KinaseIBA 02/2012 - 01/2006
3	VemurafenibIBA 01/2020 - 12/2016
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2009
3	Biological ProductsIBA 01/2020 - 08/2009
3	Contrast MediaIBA 01/2018 - 05/2006
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2017 - 04/2005
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017 - 11/2003
3	tanespimycin (17AAG)IBA 01/2017 - 11/2003
3	Pyruvic Acid (Pyruvate)IBA 12/2016 - 10/2013
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2016 - 10/2013
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2014 - 01/2006
2	AZD3965IBA 01/2020 - 11/2017
2	dipinacoline glutamateIBA 03/2019 - 01/2016
2	MK 2206IBA 10/2018 - 11/2014
2	bisbenzimide ethoxide trihydrochloride (Hoechst 33342)IBA 01/2018 - 08/2017
2	Oxygen (Dioxygen)IBA 01/2018 - 01/2016
2	Adenosine Triphosphate (ATP)IBA 12/2017 - 02/2014
2	MTOR InhibitorsIBA 07/2017 - 01/2017
2	Prostate-Specific Antigen (Semenogelase)IBA 04/2017 - 01/2016
2	Temozolomide (Temodar)FDA LinkGeneric 01/2017 - 01/2014
2	nintedanibIBA 04/2015 - 07/2008
2	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 07/2009
2	NucleosidesIBA 09/2013 - 04/2008
2	phosphorylethanolamine (phosphoethanolamine)IBA 09/2013 - 11/2003
2	Histone Deacetylase InhibitorsIBA 02/2012 - 04/2008
2	LAQ824IBA 02/2012 - 04/2008
2	ProdrugsIBA 11/2009 - 06/2009
2	Gadolinium DTPA (Magnevist)FDA Link 07/2008 - 01/2002
1	regorafenibIBA 12/2021
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2020
1	GadoliniumIBA 01/2019
1	Hormones (Hormone)IBA 12/2018
1	CollagenIBA 04/2018
1	C.I. direct red 80IBA 04/2018
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 04/2018
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2018
1	Tyrosine Kinase InhibitorsIBA 01/2018
1	Phosphotransferases (Kinase)IBA 12/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2017
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2017
1	vistusertibIBA 12/2017
1	deoxyhemoglobinIBA 08/2017
1	Messenger RNA (mRNA)IBA 07/2017
1	Caspase 3 (Caspase-3)IBA 07/2017
1	dactolisibIBA 07/2017
1	olaparibIBA 04/2017
1	CytokinesIBA 01/2017
1	Melanins (Melanin)IBA 01/2017
1	Phenobarbital (Luminal)FDA Link 01/2017
1	Monophenol Monooxygenase (Tyrosinase)IBA 01/2017
1	Alkaline PhosphataseIBA 01/2016
1	Hemoglobins (Hemoglobin)IBA 01/2016

Therapy/Procedure

14	Therapeutics 01/2021 - 04/2008
10	Radiotherapy 03/2019 - 02/2003
7	Drug Therapy (Chemotherapy) 12/2021 - 05/2006
5	Aftercare (After-Treatment) 12/2021 - 01/2006
3	Castration 04/2017 - 11/2014
1	Proton Therapy 12/2018
1	Blood Transfusion (Blood Transfusions) 01/2017
1	Chemoradiotherapy 01/2016